**Figure 2.** **Multivariable-adjusted meta-analysis comparing the effectiveness of TDF vs entecavir in reducing HCC risk.** Note that this meta-analysis is based on multivariable-adjusted risk estimates. The squares represent risk estimate of each included study, with the area reflecting the weight assigned to the study. The horizontal line across each square represents 95% CI. The diamond represents the pooled risk estimate, with width representing 95% CI. TDF, tenofovir disoproxil fumarate; HCC, hepatocellular carcinoma; HR, hazard ratio; CI, confidence interval.